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KMID : 0358819860130020155
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1986 Volume.13 No. 2 p.155 ~ p.163
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A GENETIC STUDY OF CLEFT LIP AND PALATE AND COMBINED CONGENITAL ANOMALIES
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Lee Young-Man
Kim Ing-Gon
Lew Jai-Mann
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Abstract
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There has been relatively high incidence of congenital cleft lip and palate among congenital anomalies. The etiological factors of cleft lip and palate has been studied by many workers with embryological, environmental and genetical approach, but they are still imperfectly understood. So the author reviewed 19,420 live births and 337 patients with cleft lip and cleft palate who were admitted and treated at Hanyang University hospital during past 12 years period from January 1973 to December 1984 in order to evaluate the frequency and etiological factors of cleft lip and cleft palate. At the same time, author studied 74 chromosomal structures of the cleft lip and cleft palate.
The following results were obtained;
1. The incidence of all cleft was 1.0 per 1,000 live births.
2. The rate of cleft lip and palated among congenital anomalies was 20%.
3. The rate of cleft lip, cleft lip with cleft palate and cleft palate along was 1.0 : 1.0 : 1.2.
4. Males were affected 1.2 times more than female in cleft lip and 4.3 times in cleft lip with cleft palate but in cleft palate females were affected 1.4 times more than male.
5. 18 cases (5.3%) showed positive family histories.
6. 19 cases (5.4%) had associated congenital anomalies.
7. 7 cases (9.5%) showed abnormal chromosomal structure in the chromosomal study.
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KEYWORD
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